The Laboratory for Genomics Research (LGR) is a state-of-the-art functional genomics center located near the UCSF Mission Bay campus. We have built a fully integrated, end-to-end CRISPR screening facility with deep expertise spanning automation, next-generation sequencing, computational analysis, and cell biology.

Our work advances functional genomics tool development and applies these technologies to uncover mechanisms of human disease biology. By combining large-scale screening with rigorous biological investigation, we generate insights that expand understanding of disease and accelerate therapeutic discovery.

As we continue to grow, our focus is on expanding disease area knowledge, advancing CRISPR-based technologies, and serving as a resource to the broader scientific community.

Today, LGR is a UCSF-based genomics organization advancing CRISPR technologies and enabling collaborative research across academia, industry, and philanthropic partnerships. We develop and apply next-generation functional genomics approaches across diverse disease areas, supporting both large-scale programs and independent research, and offering flexible, end-to-end capabilities from experimental design through data generation and analysis. Together, these capabilities enable us to accelerate discovery while continuing to drive innovation in the field.